2020欧洲杯在线网投

学院概况

2020欧洲杯在线网投是深圳大学于2014年成立的一个包含本科与研究生培养、侧重跨学科教学与学术研究的校内综合办学单位。作为深圳大学内部探索全面改革创新的学术特区,高等研究院与香港和海外著名高校合作,借鉴国内外研究型大学通行的管理模式,引进具有一流视野的资深教授和发展潜力的青年教师,营造与国际接轨的学术氛围和培养环境,开展卓越的教学、研究和管理工作。

资讯动态

高等研究院系列学术讲座一百二十六

发布时间:2020-10-12 | 浏览次数:

A tale of CpG and GGG: DNA modifications and structures

Speaker Dr. Shiqing Mao

Cancer Research UK Cambridge Institute, University of Cambridge


About the Speaker

Dr. Mao earned his PhD degree from Chinese Academy of Sciences at the Institute of Biochemistry and Cell Biology in 2014, and then joined Sir Shankar Balasubramanian’s lab in Cambridge University. His major interests are how epigenetic DNA modifications are inherited in mammalian system and how epigenetic information is altered in cancer and other diseases.


Talk Introduction

DNA methylation mainly refers to the methylation of the C5 position of the cytosine ring. Cytosine methylation has been shown to play important roles in the regulation of key biological processes, including tissue specific gene expression, X-chromosome inactivation, transposon silencing, and genomic imprinting. In mammalian genome, methylation level varies from regions to regions. There are regulatory elements like CpG islands (CGIs) which maintain hypomethylated throughout the genome. There are also always-hypermethylated cytosine bases across different tissues. How the distinctive patterns of DNA methylation arise remains elusive. In this talk, I will present my quest on this question in the past few years focusing on the establishment and maintenance of DNA methylation. I found that DNA structures called G-quadruplex can sequester DNMT1 thereby protect certain CGIs from methylation and inhibiting local methylation. By biochemical and epigenomic analysis, I also found that the global DNA methylation landscape of the mammalian genome can be fundamentally determined by the inherent sequence preference of de novo methyltransferases.


时间:2020年10月16日10:00-11:00

地点:汇元楼(原办公楼)103会议室

All are welcome!



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